More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/Romaciclib (monohydrochloride)

Romaciclib (monohydrochloride)

HY-111388A
MedChem Express
Estimated Purity99.29
DownloadMSDS
Product group Chemicals
Molecular Weight450.60
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    MedChem Express
  • Product Name
    SEL120-34A (monohydrochloride)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    99.29
  • Molecular Formula
    C15H19Br2ClN4
  • Molecular Weight
    450.60
  • Scientific Description
    SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC 50 =1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726 [1] . Has anti-tumor activity [1] .
  • SMILES
    CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2.Cl
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200