Sembragiline [676479-06-4]

MedChem Express

Sembragiline [676479-06-4]

5

676479-06-4

Research Use Only

C19H19FN2O3

342.36

Sembragiline (EVT 302) is a potent, selective and reversible monoamine oxidase B (MAO-B) inhibitor. Sembragiline reduces the metabolism of dopamine and other amine neurotransmitters by inhibiting the activity of the MAO-B enzyme, thereby potentially increasing the concentration of these neurotransmitters in the brain. Inhibition of the MAO-B enzyme also reduces the formation of toxic reactive oxygen species (ROS) that play a role in the pathological process of AD. Sembragiline has good oral activity and blood-brain barrier permeability. Sembragiline can be used in studies of AD, especially in patients with AD who show increased MAO-B activity[1].

CC(N[C@@H](C1)CN(C2=CC=C(OCC3=CC=CC(F)=C3)C=C2)C1=O)=O

12352200