Senexin A

MedChem Express

Senexin A [1366002-50-7]

10

1366002-50-7

Research Use Only

99.79

C17H14N4

274.32

Senexin A is an inhibitor of CDK8/19 ( IC 50 : 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-kappaB-dependent promoters [1] [2] .

N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1

-20°C,2°C to 8°C

12352200