Serpina1 Polyclonal Antibody

Reddot Biotech

Serpina1 Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Serpina1

serpin family A member 1

AAT; alpha-1-antiproteinase; alpha-1-antitrypsin (protease inhibitor); alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; Pi; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine protease inhibitor alpha 1; serpin A1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Spi1

Rabbit

IgG

SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT),which is a serine protease inhibitor whose targets include elastase,plasmin,thrombin,trypsin,chymotrypsin,and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes,with smaller amountssynthesized by intestinal epithelial cells,neutrophils,pulmonary alveolar cells and macrophages. AAT is the most abundant,endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation,fibrinolysis,complement activation,apoptosis,reproduction,tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.

Mouse, Rat

-20°C

12352203