SETD2 Polyclonal Antibody

Reddot Biotech

SETD2 Polyclonal Antibody

5

0.2 mg/ml

SETD2

SET domain containing 2, histone lysine methyltransferase

HBP231; HIF-1; HIP-1; histone-lysine N-methyltransferase SETD2; HSPC069; huntingtin interacting protein 1; huntingtin yeast partner B; huntingtin-interacting protein B; HYPB; KMT3A; LLS; lysine N-methyltransferase 3A; p231HBP; protein-lysine N-methyltransferase SETD2; SET2

Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

-20°C

12352203