SGK1 Monoclonal Antibody

Reddot Biotech

SGK1 Monoclonal Antibody

5

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

Clone:4D12

1 mg/ml

Unconjugated

SGK1

serum/glucocorticoid regulated kinase 1

serine/threonine protein kinase SGK; serine/threonine-protein kinase Sgk1; SGK; Sgk1 variant i3

Mouse

IgG

Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.

Human, Mouse, Rat

-20°C

12352203