SHANK3 Antibody: RPE

Biorbyt

SHANK3 antibody

16

1 microg/ml of SMC-336 was sufficient for detection of Shank3 in 10 microg COS cell lysate transiently transfected with Shank3 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

WB (1:1000), IHC (1:100), ICC/IF (1:100) ICC, IF, IHC, WB

Research Use Only

Monoclonal

S69

1 mg/ml

RPE

Shank3

SH3 and multiple ankyrin repeat domains 3

proline-rich synapse-associated protein 2; Prosap2; SH3 and multiple ankyrin repeat domains protein 3; SH3/ankyrin domain gene 3; Shank postsynaptic density protein 3a; Spank-2

Mouse

IgG2b

SH3 and multiple ankyrin repeat domains protein 3

Mouse monoclonal to SHANK3 (RPE). Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation. Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders..

Human, Mouse, Rat

See Manual

12352203