Shikonin (C.I. 75535) [54952-43-1]
S8279
CAS Number517-89-5
Product group Chemicals
Overview
- SupplierSelleck Chemicals
- Product NameShikonin (C.I. 75535) [54952-43-1]
- Delivery Days Customer9
- CAS Number517-89-5
- CertificationResearch Use Only
- Scientific DescriptionShikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-alfa (TNF-alfa) and prevents activation of nuclear factor-kappaB (NF-kappaB) pathway via proteasome inhibition.
- UNSPSC12352200