Shikonin (Standard)

MedChem Express

Shikonin (Standard) [517-89-5]

9

Research Use Only

Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC 50 of 6.5 microM [1] . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor [2] and can also inhibit TNF-alpha and NF-kappaB pathway [3] . Shikonin decreases exosome secretion through the inhibition of glycolysis [4] . Shikonin inhibits AIM2 inflammasome activation [7] .

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