(+)SHIN2

MedChem Express

(+)SHIN2

10

Research Use Only

99.11

C23H26N4O3

406.48

(+)SHIN2 is a serine hydroxymethyltransferase ( SHMT ) inhibitor, whose target can be traced with 13 C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519) [1] . (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

N#CC([C@@]1(C2=CC(C#CCCCO)=CC(CO)=C2)C(C)C)=C(N)OC3=C1C(C)=NN3

-20°C,2°C to 8°C

12352200