SI-2

MedChem Express

SI-2

5

Research Use Only

C15H15N5

265.31

SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 ( SRC-3 ), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) [1] .

CN1C(N/N=C(C)/C2=CC=CC=N2)=NC3=CC=CC=C13

12352200