SIAIS117 [2353494-84-3]

TargetMol Chemicals

SIAIS117 [2353494-84-3]

999

Chemical

Research Use Only

SIAIS117

C57H76ClN10O7PS

1111.77

SIAIS117, a potent Brigatinib-PROTAC degrader, effectively degrades the ALK G1202R point mutation through its design based on Brigatinib and VHL-1 conjunction. It inhibits the proliferation of SR and H2228 cancer cell lines, demonstrating potential anti-proliferative effects against small cell lung cancer [1].

3 years

COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)NC(=O)CCCCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C

-20°C

12352200