Sibiriline [1346526-26-8]

AdipoGen Life Sciences

Sibiriline [1346526-26-8]

10

1346526-26-8

Research Use Only

>98%

C13H10N2O

210.2

Chemical. CAS: 1346526-26-8. Formula: C13H10N2O. MW: 210.2. Specific competitive RIPK1 inhibitor in vitro (IC50=1.03microM). Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases. Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2microM). Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine. Protects mice from concanavalin A-induced hepatitis in vivo. - Specific competitive RIPK1 inhibitor in vitro (IC50=1.03microM). Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases. Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2microM). Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine. Protects mice from concanavalin A-induced hepatitis in vivo.

OC(C=C1)=CC=C1C2=CC3=CC=CN=C3N2

-20°C,2°C to 8°C

12352200