Silodosin-d4

MedChem Express

Silodosin-d4 [1426173-86-5]

10

1426173-86-5

C25H28D4F3N3O4

499.56

Silodosin-d 4 is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active alpha1A-adrenergic receptor (alpha1A-AR) blocker. Silodosin exhibits high affinity for alpha1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for alpha1B-AR and alpha1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH[1][3].

C(CCO)N1C=2C(=CC(C[C@H](NC(C(OC3=C(OCC(F)(F)F)C=CC=C3)([2H])[2H])([2H])[2H])C)=CC2C(N)=O)CC1

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