SIM2 Polyclonal Antibody

Reddot Biotech

SIM2 Polyclonal Antibody

5

1 mg/ml

SIM2

SIM bHLH transcription factor 2

bHLHe15; class E basic helix-loop-helix protein 15; HMC13F06; HMC29C01; SIM; single-minded family bHLH transcription factor 2; single-minded homolog 2; transcription factor SIM2

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

-20°C

12352203