Chemical Structure
Chemical Structure
Chemical Structure

SIN-1 chloride [16142-27-1]

Research Use Only
AdipoGen Life Sciences
CAS Number16142-27-1
Product group Chemicals
Estimated Purity>98% (NMR)
Molecular Weight206.6
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Packing Size
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  • Supplier
    AdipoGen Life Sciences
  • Product Name
    SIN-1 chloride [16142-27-1]
  • Delivery Days Customer
  • CAS Number
  • Certification
    Research Use Only
  • Estimated Purity
    >98% (NMR)
  • Hazard Information
  • Molecular Formula
  • Molecular Weight
  • Scientific Description
    Chemical. CAS: 16142-27-1. Formula: C6H11ClN4O2. MW: 206.6. Nitric oxide (NO) donor. Generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite. Platelet aggregation inhibitor. Guanylyl cyclase activator. Cytotoxic. Positive ionotropic. Vasodilator. - Nitric oxide (NO) donor [1]. Generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite [1]. Platelet aggregation inhibitor [2, 3]. Guanylyl cyclase activator [2, 3]. Cytotoxic [4]. Positive ionotropic [5]. Vasodilator [6].
  • Storage Instruction
    2°C to 8°C,-20°C


  • Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide: N. Hogg et al.; Biochem. J. 281, 419 (1992)
  • Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites: M. Nishikawa et al.; J. Phar.macol. Exp. Ther. 220, 183 (1982)
  • Synergistic platelet antiaggregatory effects of the adenylate cyclase activator iloprost and the guanylate cyclase activating agent SIN-1 in vivo: M. Spiecker, et al.; Thromb. Res. 70, 405 (1993)
  • SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium: K. Konishi, et al.; Nitric Oxide 20, 270 (2009)
  • cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes: M.J. Kohr, et al.; J. Mol. Cell. Cardiology 48, 645 (2010)
  • Response of coronary arteries to nitrates, the EDRF-donor SIN-1, and calcium antagonists: W. Schulz & G. Kober; Basic Res. Cardiol. 86, 233 (1991)