SIPA1L3 antibody

GeneTex

SIPA1L3 antibody

9

WB: 1 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

SIPA1L3

signal induced proliferation associated 1 like 3

CTRCT45; signal-induced proliferation-associated 1-like protein 3; SIPA1-like protein 3; SPA-1-like protein 3; SPAL3; SPAR3; spine-associated RapGAP 3

Rabbit

IgG

Signal-induced proliferation-associated 1-like protein 3

Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice (3) and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203