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Siramesine

M2592
AbMole BioScience
CAS Number147817-50-3
Product group Chemicals
Estimated Purity>99%
Molecular Weight454.58
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Siramesine
  • Delivery Days Customer
    9
  • CAS Number
    147817-50-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Estimated Purity
    >99%
  • Molecular Formula
    C30H31FN2O
  • Molecular Weight
    454.58
  • Scientific Description
    Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes.
  • SMILES
    1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine]
  • UNSPSC
    12352200