SirReal2

MedChem Express

SirReal2 [709002-46-0]

10

709002-46-0

99.0

C22H20N4OS2

420.55

SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC 50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration [1] [2] [3] [4] .

O=C(NC1=NC=C(CC2=C3C=CC=CC3=CC=C2)S1)CSC4=NC(C)=CC(C)=N4

-20°C

12352200