Sirt1/2-IN-2 [670267-73-9]

TargetMol Chemicals

Sirt1/2-IN-2 [670267-73-9]

16

Chemical

Research Use Only

Sirt1/2-IN-2

C18H14N4O3S2

398.46

Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor, targeting SIRT1 with an IC50 of 1.8 microM and SIRT2 with an IC50 of 2.4 microM. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and alpha-tubulin, promoting apoptosis and exhibiting anti-proliferative effects on human leukemia cell lines [1].

3 years

N(S(=O)(=O)C1=CC=CC=C1)C=2C3=C(C(O)=C(SC=4NC=NN4)C2)C=CC=C3

-20°C

51202000