Sirt1/2-IN-3 [301313-42-8]

TargetMol Chemicals

Sirt1/2-IN-3 [301313-42-8]

16

Chemical

Research Use Only

Sirt1/2-IN-3

C17H14ClNO4S

363.82

Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 microM (SIRT1) and 2.0 microM (SIRT2), respectively. This compound effectively inhibits p53 deacetylation while simultaneously elevating p53 and alpha-tubulin acetylation levels. Additionally, Sirt1/2-IN-3 promotes apoptosis and exhibits antiproliferative effects on human leukemia cell lines [1].

3 years

COC1=CC=C(C=C1)S(=O)(=O)NC1=C2C=CC=CC2=C(O)C(Cl)=C1

-20°C

51202000