Sitamaquine tosylate [1019640-33-5]
T37469
Overview
- SupplierTargetMol Chemicals
- Product NameSitamaquine tosylate [1019640-33-5]
- Delivery Days Customer44
- CAS Number1019640-33-5
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameSitamaquine tosylate
- Molecular FormulaC28H41N3O4S
- Molecular Weight515.71
- Scientific DescriptionSitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 microM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 microM.2Sitamaquine (100 microM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes.
- Shelf life instruction3 years
- SMILESCc1ccc(cc1)S(O)(=O)=O.CCN(CC)CCCCCCNc1cc(OC)cc2c(C)ccnc12
- Storage Instruction-20°C
- UNSPSC12352200