SKA2 Antibody, Biotin conjugated
CSB-PA823890LD01HU
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetSKA2
Overview
- SupplierCusabio
- Product NameSKA2 Antibody, Biotin conjugated
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateBiotin
- Gene ID348235
- Target nameSKA2
- Target descriptionspindle and kinetochore associated complex subunit 2
- Target synonymsFAM33A; family with sequence similarity 33, member A; spindle and kinetochore-associated protein 2; spindle and KT (kinetochore) associated 2
- HostRabbit
- IsotypeIgG
- Protein IDQ8WVK7
- Protein NameSpindle and kinetochore-associated protein 2
- Scientific DescriptionComponent of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203