SKA3 Antibody, HRP conjugated

Cusabio

SKA3 Antibody, HRP conjugated

20

ELISA

Research Use Only

Polyclonal

HRP

SKA3

spindle and kinetochore associated complex subunit 3

C13orf3; RAMA1; spindle and kinetochore-associated protein 3

Rabbit

IgG

Spindle and kinetochore-associated protein 3

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).

Human

-20°C or -80°C

12352203