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SKI-178 [1259484-97-3]

SKI-178 [1259484-97-3]

T9014
TargetMol Chemicals
CAS Number1259484-97-3
DownloadMSDS
Product group Chemicals
Estimated Purity0.99
Molecular Weight394.42
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SKI-178 [1259484-97-3]
  • Delivery Days Customer
    4
  • CAS Number
    1259484-97-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    SKI-178
  • Estimated Purity
    0.99
  • Molecular Formula
    C21H22N4O4
  • Molecular Weight
    394.42
  • Scientific Description
    SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 microM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
  • Shelf life instruction
    3 years
  • SMILES
    COc1ccc(cc1)-c1cc([nH]n1)C(=O)N\N=C(/C)c1ccc(OC)c(OC)c1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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