SKLB-197

MedChem Express

SKLB-197 [2713577-16-1]

10

2713577-16-1

Research Use Only

99.91

C25H24N6O

424.50

SKLB-197 showed an IC50 value of 0.013 microM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.

CN1N=CC=C1C2=CC3=C(N4[C@H](C)COCC4)N=C(C5=CC=CC6=C5C=CN6)N=C3C=C2

-20°C,2°C to 8°C

12352200