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Western blot analysis of extracts from HeLa cells, COS-7 cells, HepG2 cells and HUVEC cells, using Smad4 antibody.
Western blot analysis of extracts from HeLa cells, COS-7 cells, HepG2 cells and HUVEC cells, using Smad4 antibody.
Western blot analysis of extracts from HeLa cells, COS-7 cells, HepG2 cells and HUVEC cells, using Smad4 antibody.

SMAD4 Antibody

Research Use Only
CSB-PA825890
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetSMAD4
Price on request
Packing Size
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    Cusabio
  • Product Name
    SMAD4 Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID4089
  • Target name
    SMAD4
  • Target description
    SMAD family member 4
  • Target synonyms
    deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; DPC4; JIP; MAD homolog 4; MADH4; mothers against decapentaplegic homolog 4; mothers against decapentaplegic, Drosophila, homolog of, 4; MYHRS; SMAD, mothers against DPP homolog 4
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ13485
  • Protein Name
    Mothers against decapentaplegic homolog 4
  • Scientific Description
    In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 By similarity. Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Hahn S.A., Science 271:350-353(1996). Zhang Y., Nature 383:168-172(1996). Moskaluk C.A., Diagn. Mol. Pathol. 6:85-90(1997).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203