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SMAD4 (Pancreatic Adenocarcinoma Marker)(SMAD4/2524), CF405S conjugate, 0.1mg/mL [26628-22-8]

SMAD4 (Pancreatic Adenocarcinoma Marker)(SMAD4/2524), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042524
Biotium
ReactivityBovine, Human, Mouse
Product group Antibodies
TargetSMAD4
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Overview

  • Supplier
    Biotium
  • Product Name
    SMAD4 (Pancreatic Adenocarcinoma Marker)(SMAD4/2524), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    SMAD4/2524
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID4089
  • Target name
    SMAD4
  • Target description
    SMAD family member 4
  • Target synonyms
    deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; DPC4; JIP; MAD homolog 4; MADH4; mothers against decapentaplegic homolog 4; mothers against decapentaplegic, Drosophila, homolog of, 4; MYHRS; SMAD, mothers against DPP homolog 4
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDQ13485
  • Protein Name
    Mothers against decapentaplegic homolog 4
  • Scientific Description
    Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4. Upon ligand binding, the receptors of the TGF- family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus, where they activate transcription. To carry out this function, the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma, locus 4 (DPC4), also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor, since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. SMAD4 is absent in approximately 80% of pancreatic adenocarcinoma, but rarely in endometrial, colorectal, ovarian, lung, breast adenocarcinomas, and malignant melanom. SMAD4 is an important marker for confirming a diagnosis of pancreatic adenocarcinoma. Patients with pancreatic adenocarcinomas with SMAD4 protein expression had significantly longer survival than SMAD4 negative patients. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203