Immunohistochemistry of paraffin-embedded Human cervical cancer using SMAD4 Polyclonal Antibody at dilution of 1/40
Immunohistochemistry of paraffin-embedded Human cervical cancer using SMAD4 Polyclonal Antibody at dilution of 1/40
SMAD4 Polyclonal Antibody
E-AB-16957
Product group Antibodies
Overview
- SupplierElabscience
- Product NameSMAD4 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
- UNSPSC12352203