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SMAD7 Antibody, Biotin conjugated

CSB-PA021793LD01HU
Cusabio
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetSMAD7
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Overview

  • Supplier
    Cusabio
  • Product Name
    SMAD7 Antibody, Biotin conjugated
  • Delivery Days Customer
    20
  • Applications
    ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Biotin
  • Gene ID4092
  • Target name
    SMAD7
  • Target description
    SMAD family member 7
  • Target synonyms
    CRCS3; hSMAD7; MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 8; MADH7; MADH8; mothers against decapentaplegic homolog 7; Mothers against decapentaplegic, drosophila, homolog of, 7; mothers against DPP homolog 8; SMAD, mothers against DPP homolog 7
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO15105
  • Protein Name
    Mothers against decapentaplegic homolog 7
  • Scientific Description
    Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203