SMARCA2 Antibody, Biotin conjugated

Cusabio

SMARCA2 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

ATP-dependent helicase SMARCA2; BAF190; BAF190B; BIS; brahma homolog; BRG1-associated factor 190B; BRM; global transcription activator homologous sequence; hBRM; hSNF2a; NCBRS; probable global transcription activator SNF2L2; protein brahma homolog; SNF2; SNF2/SWI2-like protein 2; SNF2-alpha; SNF2L2; SNF2LA; Sth1p; sucrose nonfermenting 2-like protein 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI2

Rabbit

IgG

Probable global transcription activator SNF2L2

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Human

-20°C or -80°C

12352203