SMARCC2 Antibody

Cusabio

SMARCC2 Antibody

20

Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

SMARCC2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2

BAF170; chromatin remodeling complex BAF170 subunit; CRACC2; CSS8; mammalian chromatin remodeling complex BRG1-associated factor 170; Rsc8; SWI/SNF complex 170 kDa subunit; SWI/SNF complex subunit SMARCC2; SWI3-like protein

Rabbit

IgG

SWI/SNF complex subunit SMARCC2

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth

Human

-20°C or -80°C

12352203