SMG7 Polyclonal Antibody

Reddot Biotech

SMG7 Polyclonal Antibody

5

Western Blot

Research Use Only

1 mg/ml

Unconjugated

SMG7

SMG7 nonsense mediated mRNA decay factor

breast cancer-associated antigen SGA-56M; C1orf16; EST1 telomerase component homolog C; EST1C; EST1-like protein C; ever shorter telomeres 1C; protein SMG7; SGA56M; smg-7 homolog, nonsense mediated mRNA decay factor

Rabbit

IgG

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Human, Mouse, Rat

-20°C

12352203