SMG8 Polyclonal Antibody

Reddot Biotech

SMG8 Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.3 mg/ml

Unconjugated

SMG8

SMG8 nonsense mediated mRNA decay factor

ALKUS; amplified in breast cancer gene 2 protein; C17orf71; protein SMG8; protein smg-8 homolog; smg-8 homolog, nonsense mediated mRNA decay factor

Rabbit

IgG

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

Human, Mouse

-20°C

12352203