SMN1/SMN2 blocking peptide
GTX89136-PEP
Product group Proteins / Signaling Molecules
Overview
- SupplierGeneTex
- Product NameSMN1/SMN2 blocking peptide
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionThis gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve t
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352202