SMUG1 Antibody

Cusabio

SMUG1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

SMUG1

single-strand-selective monofunctional uracil-DNA glycosylase 1

FDG; HMUDG; single-strand selective monofunctional uracil DNA glycosylase; UNG3

Rabbit

IgG

Single-strand selective monofunctional uracil DNA glycosylase

Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA. Ide H., Biochemistry 42:5003-5012(2003). Sugano S., Nat. Genet. 36:40-45(2004). Venter J.C., Submitted (JUL-2005).

Human

-20°C or -80°C

12352203