SN-398

MedChem Express

SN-398

5

Research Use Only

C22H19FN2O5

410.40

SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I ( Topo I ), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) ( IC 50 =1.562 microM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells [1] .

O=C1N2C(C(C(C2)=C(C3=C4)CC)=NC3=CC(F)=C4O)=CC5=C1COC([C@]5(O)CC)=O

12352200