SNAP23 antibody

GeneTex

SNAP23 antibody

9

WB: 1-2 microg/ml. ICC/IF: 2 microg/ml. FACS: 3-5 microg/106 cells. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Snap23

synaptosomal-associated protein 23

23kDa; AA408749; Sn; SNA; SNAP-23; Sndt; synaptosomal-associated protein 23; synaptosomal-associated protein, 23kD; Synd; Syndet; vesicle-membrane fusion protein SNAP-23

Rabbit

IgG

Synaptosomal-associated protein 23

Synaptosomal-associated proteins (SNAPs) are cytosolic proteins that play a key role in in the process of membrane fusion in intracellular vesicle trafficking. In eukaryotic cells, the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex is critical to membrane docking and fusion and is believed to impart some degree of specificity between vesicle SNARE (v-SNARE) and target organelle SNARE (t-SNARE). In neurons and neuroendocrine cells, the SNARE complex consists of the integral membrane proteins VAMP (vesicle-associated membrane protein), syntaxin and SNAP-25. In non-neuronal tissue, a SNAP-25 homolog, SNAP-23, functionally replaces SNAP-25 in the SNARE complex. Studies show that VAMP, syntaxin and SNAP-23 are required for SNARE function and that this complex exists as a heterotrimer of the three proteins. In insulin signalling pathways, studies suggest that the translocation of GLUT4 in adipocytes requires that functional SNAP-23 be present in SNARE complexes.

Bovine, Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203