Chemical Structure
Chemical Structure
Chemical Structure

SNC80 [156727-74-1]

Research Use Only
AdipoGen Life Sciences
CAS Number156727-74-1
Product group Chemicals
Estimated Purity>99% (NMR)
Molecular Weight449.6
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  • Supplier
    AdipoGen Life Sciences
  • Product Name
    SNC80 [156727-74-1]
  • Delivery Days Customer
  • CAS Number
  • Certification
    Research Use Only
  • Estimated Purity
    >99% (NMR)
  • Hazard Information
  • Molecular Formula
  • Molecular Weight
  • Scientific Description
    Chemical. CAS: 156727-74-1. Formula: C28H39N3O2. MW: 449.6. Highly selective and potent non-peptide delta-opioid receptor agonist. Mediates downregulation of the delta-opioid receptor. Shows antidepressant-like effects. Modulates voltage-dependent sodium channels. Antinociceptive. Activates ATP-sensitive K+ channels. Enhances amphetamine-mediated dopamine efflux. - Highly selective and potent non-peptide delta-opioid receptor agonist [1-3]. Mediates downregulation of the delta-opioid receptor [4]. Shows antidepressant-like effects [5, 8]. Modulates voltage-dependent sodium channels [6]. Antinociceptive [7]. Activates ATP-sensitive K+ channels [7]. Enhances amphetamine-mediated dopamine efflux [9].
  • Storage Instruction
    2°C to 8°C


  • Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4- [(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist: S.N. Calderon, et al.; J. Med. Chem. 37, 2125 (1994)
  • SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist: E.J. Bilsky, et al.; J. Pharmacol. Exp. Ther. 273, 359 (1995)
  • Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors: R.J. Knapp, et al.; J. Pharmacol. Exp. Ther. 277, 1284 (1996)
  • Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin: T. Okura, et al.; Eur. J. Pharmacol. 387, R11 (2000)
  • Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents: A. Saitoh, et al.; J. Pharmacol. Sci. 95, 374 (2004)
  • Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons: C. Remy, et al.; Neuropharmacology 47, 1102 (2004)
  • Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels: D.F. Pacheco & I.D. Duarte; Eur. J. Pharmacol. 512, 23 (2005)
  • Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model: A. Saitoh, et al.; Brain Res. 1208, 160 (2008)
  • The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum: K.E. Bosse, et al.; Neuropharmacology 55, 755 (2008)