SNIPER(ER)-87 [2222354-91-6]

TargetMol Chemicals

SNIPER(ER)-87 [2222354-91-6]

999

2222354-91-6

Chemical

Research Use Only

SNIPER(ER)-87

C59H73N5O10S

1044.32

SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor alpha (ERalpha) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERalpha protein with an IC50 value of 0.097 microM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERalpha, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERalpha induced by SNIPER(ER)-87[1][2].

3 years

[H][C@]1(CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)c1nc(cs1)C(=O)c1cccc(OCCOCCOCCOCC(=O)N(C)CCOc2ccc(cc2)C(=C(CC)c2ccccc2)c2ccc(O)cc2)c1 - w:58.61 -

-20°C

12352200