SNX27 Antibody, HRP conjugated
CSB-PA842704LB01HU
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetSNX27
Overview
- SupplierCusabio
- Product NameSNX27 Antibody, HRP conjugated
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateHRP
- Gene ID81609
- Target nameSNX27
- Target descriptionsorting nexin 27
- Target synonymsmethamphetamine-responsive transcript 1; MRT1; MY014; sorting nexin family member 27; sorting nexin-27
- HostRabbit
- IsotypeIgG
- Protein IDQ96L92
- Protein NameSorting nexin-27
- Scientific DescriptionInvolved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203