SOD (EC) Antibody: RPE

Biorbyt

SOD (EC) antibody

16

1 microg/ml of SMC-167 was sufficient for detection of EC-SOD in 20 microg of human cartilage lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

WB (1:1000), IHC (1:100), ICC/IF (1:100) ICC, IF, IHC, WB

Research Use Only

Monoclonal

4GG11G6

1 mg/ml

RPE

SOD3

superoxide dismutase 3

EC-SOD; extracellular superoxide dismutase [Cu-Zn]; superoxide dismutase 3, extracellular; testicular tissue protein Li 175

Mouse

IgG1

Extracellular superoxide dismutase [Cu-Zn]

Mouse monoclonal to SOD (RPE). Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2 to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2, 5). In general, SODs play a major role in antioxidant defense mechanisms. There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge. The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space. SOD3 can also be distinguished by its heparin-binding capacity..

Guinea Pig, Human, Mouse, Rat

See Manual

12352203