Sodium/Potassium ATPase alpha 1 antibody [M7-PB-E9]

GeneTex

Sodium/Potassium ATPase alpha 1 antibody [M7-PB-E9]

9

This antibody recognizes an epitope between amino acid residues 646 and 652 of the sheep kidney alpha sodium/potassium ATPase. In rat, this antibody can only detects the alpha 3 isoform.

WB: 1:500-1:5000. ICC/IF: 1:20. IHC-P: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

M7-PB-E9

Unconjugated

ATP1A1

ATPase Na+/K+ transporting subunit alpha 1

Na(+)/K(+) ATPase alpha-1 subunit; sodium pump 1; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase alpha-1 chain; sodium/potassium-transporting ATPase subunit alpha-1

Mouse

IgG1

Sodium/potassium-transporting ATPase subunit alpha-1

The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha subunit has been found in kidney, brain, heart, and to a lesser extent liver, skeletal and smooth muscle.

Bovine, Canine, Chicken, Human, Mouse, Porcine, Rat, Sheep

-20°C or -80°C,2°C to 8°C

12352203