Sorafenib free base (BAY-43-9006)

Biorbyt

Sorafenib free base (BAY-43-9006) [284461-73-0]

16

284461-73-0

Research Use Only

C21H16ClF3N4O3

464.82

Sorafenib(BAY 43-9006) is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively, BAY 43-9006 suppresses both wild-type and V599E mutant BRAF activity in vitro.

C(C(NC)=O)1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=C1

12352200