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ProductsBack/SOX10(SOX10/992), CF405S conjugate, 0.1mg/mL [26628-22-8]
SOX10(SOX10/992), CF405S conjugate, 0.1mg/mL [26628-22-8]

SOX10(SOX10/992), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC040992
Biotium
ApplicationsWestern Blot
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetSOX10
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Overview

  • Supplier
    Biotium
  • Product Name
    SOX10(SOX10/992), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    SOX10/992
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID6663
  • Target name
    SOX10
  • Target description
    SRY-box transcription factor 10
  • Target synonyms
    DOM; dominant megacolon, mouse, human homolog of; PCWH; SRY (sex determining region Y)-box 10; SRY-box 10; SRY-related HMG-box gene 10; transcription factor SOX-10; WS2E; WS4; WS4C
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP56693
  • Protein Name
    Transcription factor SOX-10
  • Scientific Description
    Recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203