Sp-Thymidine-5-O-(1-thiotriphosphate) sodium

TargetMol Chemicals

Sp-Thymidine-5-O-(1-thiotriphosphate) sodium

999

Chemical

Research Use Only

Sp-Thymidine-5'-O-(1-thiotriphosphate) sodium

C10H13N2O13P3S.4Na

586.16

Sp-Thymidine-5-O-(1-thiotriphosphate) (Sp-TTP-alpha-S), an isomer of the sulfur-containing nucleotide derivative TTP-alpha-S, exhibits affinity for HIV-1 reverse transcriptase with dissociation constants (Kds) of 2.88, 4.23, and 20.21 microM in the presence of magnesium, manganate, and cobalt, respectively. Additionally, Sp-TTP-alpha-S effectively inhibits the enzyme deoxynucleoside triphosphate triphosphohydrolase SAMHD1 with an inhibition constant (Ki) of 46 nM.

3 years

O[C@@H](C1)[C@H](O[C@H]1N2C=C(C)C(NC2=O)=O)CO[P@@](OP([O-])(OP([O-])([O-])=O)=O)([S-])=O.[Na+].[Na+].[Na+].[Na+]

-20°C

12352200