Western blot analysis of extracts from HT29 cells, using SP100 antibody.
Western blot analysis of extracts from HT29 cells, using SP100 antibody.
SP100 Antibody
CSB-PA102856
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetSP100
Overview
- SupplierCusabio
- Product NameSP100 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID6672
- Target nameSP100
- Target descriptionSP100 nuclear antigen
- Target synonymslysp100b; nuclear autoantigen Sp-100; nuclear dot-associated Sp100 protein; SP100-HMG nuclear autoantigen; speckled 100 kDa
- HostRabbit
- IsotypeIgG
- Protein IDP23497
- Protein NameNuclear autoantigen Sp-100
- Scientific DescriptionTogether with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to . Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to . Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. Dent A.L., Blood 88:1423-1426(1996). Seeler J.-S., Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998). Szostecki C., J. Immunol. 145:4338-4347(1990).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203