SPD304

Biorbyt

SPD304 [869998-49-2]

16

869998-49-2

Research Use Only

C32H32F3N3O2

547.6105986

SPD304 is a selective inhibitor of tumor necrosis factor alpha (TNFalpha) and promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor, with an IC50 of 22 microM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-alpha.

CN(CCN(C)CC1C2C(=CC=CC=2)N(C=1)C3C=C(C=CC=3)C(F)(F)F)CC4C(=O)C5C(OC=4)=CC(C)=C(C)C=5

12352200