SPRTN Polyclonal Antibody

Reddot Biotech

SPRTN Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

SPRTN

SprT-like N-terminal domain

C1orf124; DNA damage protein targeting VCP; DNA damage-targeting VCP (p97) adaptor; DNA-dependent metalloprotease SPRTN; DVC1; PRO4323; spartan; zinc finger RAD18 domain-containing protein

Rabbit

IgG

The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified.

Human, Mouse, Rat

-20°C

12352203