Bio-Connect
Squamous Cell Carcinoma Antigen 1(CPTC-SERPINB3-2), CF405S conjugate, 0.1mg/mL [26628-22-8]

Squamous Cell Carcinoma Antigen 1(CPTC-SERPINB3-2), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042250
Biotium
ApplicationsWestern Blot
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetSERPINB3
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Biotium
  • Product Name
    Squamous Cell Carcinoma Antigen 1(CPTC-SERPINB3-2), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    CPTC-SERPINB3-2
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID6317
  • Target name
    SERPINB3
  • Target description
    serpin family B member 3
  • Target synonyms
    HsT1196; protein T4-A; SCC; SCCA1; SCCA-1; SCCA-PD; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; serpin B3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; squamous cell carcinoma antigen 1; SSCA1; T4-A
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP29508
  • Protein Name
    Serpin B3
  • Scientific Description
    Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203